出處
PHYTOTHERAPY RESEARCH, VOL. 6, 300-304 (1992
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題目
Antitumour Activity of Ganoderma Lucidum, an Edible Mushroom,
on Intraperitoneally Implanted Lewis Lung Carcinoma in Synergenic
Mice
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作者
E. Furusawa, S.C. Chou, S. Furusawa, A. Hirazumi and Y. Dang
Department of Pharmacology, John A. Burns School of Medicine, University
of Hawaii, Honolulu, Hawaii, USA
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論文摘要
The antitumour activity of Ganoderma Lucidum, called 'ling-Zhi
or holy mushroom' in Chinese traditional medicine, was investigated
on intraperitoneally implanted Lewis lung carcinoma in syngeneic
C57BL/6 mice. An aqueous extract of Ling-Zhi significantly increased
the life span of tumour-implanted mice, when administered intraperitoneally
alone or in combination with cytotoxic antitumour drugs (adriamycin,
fluorouracil, thioguanine, methotrexate, Cisplation) or a synthetic
immunomodulator (imexon). The aqueous extract was not cytotoxic
in cell cultures and the antitumour activity was abolished by pretreatment
of mice with cyclosporine. The active principle(s) was found to
be present predominantly in the ethanol precipitable fraction of
the aqueous extract.
Keywords: antitumour; mushroom; Lewis lung carcinoma; Mice.
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