Wang-Chi Chen, Dou-Mong Hau, Chin-Chun
Wang, I-Hsin Lin, and Shiuh-Sheng Lee
Insitute of Radiation Biology, National Tsing Hau University, 101.
Section 2. Kuang Fu Road, Hsinchu, Taiwan
Department of Common Subject, Chung San Medical and Dental College,
Department of Chinese Medicine and Hospital, China Medical College,
Department of Biochemistry, National Yang-Ming Medical College,
To whom correspondence should be addressed
（Accepted for publication May 5, 1995）
Abstract: Effects of Ganoderma Lucidum(Gl) and Krestin(PSK)
extracts on spleen , thymus and splenocytes in γ-irradiated mice
were investigated in this study. ICR strain male mice were divided
into five groups. Group A is normal control. Group B, the experimental
control, was treated with Gl. Group C, the radiation treatment control,
was treated with whole body exposure to 4 Gyγ-irradiation (RT).
Group D was treated with RT and Gl. Group E was treated with RT
and PSK. The dosage of Gl was 400 mg/day/kg body weight and PSK
was 500 mg/day/kg body weight. Our results indicated that the relative
thymus weight in Groups D and E were higher than group C on day
28 after γ-irradiation, Group D was the highest in all the experimental
groups. CD4 and CD8 splenocytes in group D were higher than group
C on days 7 and 28. Gl was better than PSK in repairing the damaged
of subset T-cells in the spleen ofγ-irradiated mice.